MersV1, Main, Exploration, bibRecord, 005382

SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

Identifieur interne : 005382 ( Main/Exploration ); précédent : 005381; suivant : 005383

SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

Auteurs : Ali A. Rabaan [Arabie saoudite] ; Shamsah H. Al-Ahmed [Arabie saoudite] ; Shafiul Haque [Arabie saoudite] ; Ranjit Sah [Népal] ; Ruchi Tiwari [Inde] ; Yashpal Singh Malik [Inde] ; Kuldeep Dhama [Inde] ; M Iqbal Yatoo [Inde] ; D Katterine Bonilla-Aldana ; Alfonso J. Rodriguez-Morales [Colombie]

Source :

Le infezioni in medicina [ 1124-9390 ]

RBID : pubmed:32275259

Descripteurs français

KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Pandémies, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- épidémiologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Humains, Pandémies.

English descriptors

KwdEn :
- Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Betacoronavirus (pathogenicity), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Pandemics, SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology).
MESH :
- epidemiology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- genetics : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- isolation & purification : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Humans, Pandemics.

Abstract

The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.

PubMed: 32275259

Affiliations:

Arabie saoudite, Colombie, Inde, Népal

Le document en format XML

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<front><div type="abstract" xml:lang="en">The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.</div>
</front>
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</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005382 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005382 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32275259
   |texte=   SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32275259" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.